Abstract
Studies have shown that many genes that regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation‐induced non‐coding RNA (TINCR) regulates the migration and invasion of a variety of tumor cells and is associated with susceptibility to various diseases. However, whether the lncRNA TINCR polymorphism is associated with susceptibility to recurrent miscarriage is unclear. Therefore, we investigated the relationship between the rs2288947 A > G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR = 0.904, 95% CI = 0.647‐1.264, P = 0.5552; GG and AA: adjusted OR = 0.871, 95% CI = 0.475‐1.597, P = 0.6542; dominant model: AG/GG vs AA: adjusted OR = 0.898, 95% CI = 0.653‐1.236, P = 0.5101; and recessive model: GG vs AA/AG: adjusted OR = 0.910, 95% CI = 0.505‐1.639, P = 0.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A > G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population. A larger multicenter study is needed to confirm our conclusions.
Highlights
Recurrent miscarriage is a multifactorial disease, and the cause is un‐ known in approximately half of the patients with recurrent spontaneous abortion.[1]
In the current case‐control study with 248 patients and 396 healthy controls from a Southern Chinese population, we did not observe a significant relationship between the Terminal differentiation‐induced non‐coding RNA (TINCR) gene rs2288947 A > G polymorphism and the recurrent spontaneous abortion susceptibility of women in Southern China
To the best of our knowledge, this is the first study to investigate the relationship between the TINCR gene rs2288947 A > G polymorphism and the susceptibility to recurrent miscarriage
Summary
Recurrent miscarriage is a multifactorial disease, and the cause is un‐ known in approximately half of the patients with recurrent spontaneous abortion.[1] The occurrence of recurrent miscarriage is associated with genetics, uterine abnormalities, thrombotic tendency, hormone or met‐ abolic disorders, infection, autoimmunity, age, and lifestyle problems.[1] Studies have found that susceptibility genes have an important relation‐ ship to the pathogenesis of recurrent spontaneous abortion.[2] In recent years, with the increase in research on recurrent abortion, an increasing number of susceptibility genes, such as MMP2, MMP9, CTLA4, FOXP3, and THBD, have been found to be associated with susceptibility to re‐ current miscarriage.[3,4,5,6] In addition, studies have confirmed that some genes that regulate cell migration are associated with susceptibility to re‐ current miscarriage[7,8] Studies have found that long non‐coding RNA (lncRNA) polymorphisms are associated with recurrent miscarriage. In the early stage, we studied MALAT1, which regulates cell migration and is associated with susceptibility to recurrent miscarriage. There have been no previous studies on the association between TINCR polymorphism rs2288947 A > G and recurrent miscarriage; we conducted this study
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