Abstract
A novel "Powder Solution Technology" involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of Avicel ® PH 200 and Aerosil ® PH 200 from 50:1 ratio to 5:1 and in which the drug is dispersed in an almost molecularly state. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are used as vehicles.
Highlights
The poor dissolution characteristics of water insoluble drugs are a major challenge for pharmaceutical science
During the past few years many techniques have been developed such as drug micronization, solid dispersions, coprecipitation, lyophilization, micro– encapsulation, use of pro-drug and drug derivatization processes, and inclusion of drug solutions into soft gelatin capsules (Kapsi, 2001)
In the case of soft gelatin capsules, Ebert’s (1977) review stated that these products demonstrated the most efficient bio availability since the drug is already in solution form
Summary
The poor dissolution characteristics of water insoluble drugs are a major challenge for pharmaceutical science. These liquid medications may be regenerated into dry – looking or moistureless, nonadherent free-flowing and readily compressible powders by a simple admixture with selected carriers and coating materials In this technique, the drug might be in solid dosage form and dissolved in solution or a solvent. The liquisolid technique systems refers to powdered forms of liquid medications formulated by changing to liquid lipophilic drugs or drug suspensions or solutions of water insoluble solid drugs in suitable non-volatile solvent systems into dry-looking, non-adherent, free moderately flowing. 3) In order to achieve acceptable flow ability and compactability for liquisolid powder formulation, high levels of carrier material and coating materials should be added This will increase the weight of tablets to above one gram which makes them difficult to swallow. Dissolution profile enhancement occurs in the presence of low levels of hydrophilic carrier, where coating material is not significant
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