The In vivo Trend Analysis of Kidney Function Indices and Lipid Profile of Albino Rats Administered Palm-Wine

Abstract

The present study evaluated the dynamics of kidney function indices and lipid profile of albino rats after administration of palm-wine to them. The fresh palm-wine was collected from a local palm-wine tapper on daily basis and divided in to two portions. The first portion was labelled “Fresh palm-wine” and administered (15 ml/kg) to group 2 and (30 ml/kg) to group 4, the second portion was allowed to ferment for additional ten hours and labelled “prolonged-fermented palm-wine” and administered (15 ml/kg) to group 3 and (30 ml/kg) to group 5. Group one served as the control and received distilled water, all for 28 days. Each group was randomly allocated four rats. Results (mmol/ml) revealed a significantly(p<0.05) lower concentration of urea (10.21±0.40), higher creatinine (0.37±0.17), K+ (4.06±0.06) and Cl- (86.12±4.61) in group 2 when compared to the control; 11.035±.110, 0.395±0.06, 3.945±.064, 80.090±0.25 respectively. In group 3, the concentrations of urea (11.70±0.35), creatinine (0.42±0.12) and Cl- (88.57±0.50) were significantly (p<0.05) higher when compared to the control. Na+ (120.09±10.40) was significantly (p<0.05) higher in group 4 when compared to the control (100.065±0.75). TAG (in mg/dL) (2.18±0.10) was significantly(p<0.05) higher in group 2 compared to control (1.96±0.023). T. cholesterol (3.125±0.27) and LDL-C (1.64±0.47) were significantly (p<0.05) lower in group 3 compared to the control; 1.99±0.052, respectively with significantly(p<0.05) elevated HDL (1.11±0.22) compared to control (0.840±0.092). TAG (2.190±0.25) and HDL-C (1.15±0.23) increased significantly(p<0.05) while LDL-C (1.58±0.14) decreased significantly (p<0.05) in group 4 compared to control; 1.960±0.023, 0.840±0.092, 1.985±0.052 respectively. T. cholesterol (2.93±0.08) and LDL-C (1.56±0.03) decreased significantly(p<0.05) with significant(p<0.05) increase in HDL-C (0.99±0.10) in group 5 compared to the control. Fresh and prolonged-fermented palm-wine may adversely affect kidney function indices and lipid profile.