Effect of Soybean Oil Supplemented Diet on Fatty Acid Level and Lipid Profile of Albino Rats

Friday O Uhegbu,Kingsley C Nwoku,Victor C Ude,Amadike E Ugbogu

doi:10.19026/bjpt.4.5395

Abstract

This aim of this study is to evaluate the effect of soybean oil supplemented diet on the fatty acid level and lipid profile of male albino rats. Forty healthy male albino rats weighing between 96-110 g and aged 6 weeks were used. The rats were placed randomly into four groups of ten animals each. Group 1 served as control and had no soybean oil in their feed. Group 2-4 was placed on soybean oil supplemented diet 10, 20 and 30% respectively. The experiment lasted for 14 days. The results showed that the animals had significant (p<0.05) increase in body weight compared with the control. Triacylglycerol, phospholipid and total cholesterol level were also significantly (p<0.05) decreased, 80.46±3.76 to 78.46±3.22; 15.36±0.34 to 10.12±0.75; and 116.65±6.38 to 110.95±6.36 mg/dL respectively. Very Low Density Lipoprotein (VLDL) and Low Density Lipoprotein (LDL) were also significantly decreased, 15.56±2.56 to 13.45±2.76; 68.88±2.54 to 56.59±2.14 mg/dL respectively. However High Density Lipoprotein (HDL) showed significant (p<0.05) increase 60.37±1.36 to 65.75±1.89 mg/dL. Cholesterol, triacylglycerol and fatty acids are significant and independent risk factors of adverse cardiovascular events. The clinical and nutritional implication of these results is discussed.

Highlights

Fatty acids are carboxylic acids with hydrocarbon chains ranging from 4 to 36 carbons
The present study investigated the effects of soybean oil supplemented diet on fatty acid levels and lipid profile of Albino rats
The results of the present study showed that consumption of soybean oil can help in reducing the risk of hyperlipidemia and atherosclerosis which is in agreement with the report of Luc and Fruchart (1991) and Poveda et al (2005)

Summary

Introduction

Fatty acids are carboxylic acids with hydrocarbon chains ranging from 4 to 36 carbons. The main pathway for denovo synthesis of fatty acids (lipogenesis) occurs in the cytosol. This system is present in many tissues, including the kidney, liver, brain, lung, mammary gland and adipose tissue (Kim, 1997). The rate is high in the well-fed animal whose diet contains a high proportion of carbohydrate. It is depressed under conditions of restricted caloric intake, especially on a fat diet or when there is a deficiency of insulin as in diabetes mellitus (Wardlaw and Kessel, 2002)

Methods

Discussion

Conclusion