Abstract
Bronchial asthma (BA) remains one of the most common chronic respiratory diseases in childhood. BA develops with a combination of genetic predisposition and environmental factors. Epidemiological data on the development of BA emphasize the role of early-life microbiota in the formation of immune responses and susceptibility to the development of BA. In recent years, enough data has been accumulated to suggest that an imbalance in intestinal and airway microbiota during early life may predispose a child to the development of BA. In turn, the biodiversity of the environment influences the colonization of various biotopes in the human body by microorganisms. The study of the mechanisms of interaction between microbiota communities of the environment and humans will pave the way for the development of new strategies for the prevention of BA.The aim of this review was to analyze current research aimed at assessing the importance of biodiversity of human microbiota and environment in the susceptibility to the development of BA in children.
Published Version
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