Abstract
BackgroundThe aim of this study was to investigate the impact of TSH levels on clinical outcomes 14 days after frozen-thawed embryo transfer.MethodsBlood samples were collected on the first visit to our department and 14 days after embryo transfer. Women were divided into three groups based on D14 TSH levels, which were compared to basal TSH levels in groups with different clinical outcomes. TSH levels between pregnant and nonpregnant women were also compared.ResultsThe clinical pregnancy rate in women with lower TSH levels 14 days after transfer was slightly but significantly lower (56%, P = 0.05) compared to those with higher TSH levels. Furthermore, TSH levels were significantly elevated 14 days after transfer compared to basal TSH levels in pregnant women and in women who successfully became pregnant (P < 0.001, respectively).ConclusionsElevated TSH levels 14 days after embryo transfer compared to basal TSH levels seem to play a protective role and predict favorable clinical outcomes under specific conditions.
Highlights
The aim of this study was to investigate the impact of TSH levels days after FET (TSH) levels days after frozenthawed embryo transfer (FET) (TSH) levels on clinical outcomes 14 days after frozen-thawed embryo transfer
Plain English Some studies have observed increased TSH levels 14 days (D14 TSH) after fresh ET; few studies have focused on the impact of D14 TSH after frozenthawed embryo transfer (FET) on clinical outcomes
Though some studies have reported increased D14 TSH after fresh ET, few studies have focused on the impact of D14 TSH after frozen-thawed embryo transfer (FET) on clinical outcomes, the ideal D14 TSH after FET, whether this parameter matters for clinical outcomes
Summary
The aim of this study was to investigate the impact of TSH levels on clinical outcomes 14 days after frozen-thawed embryo transfer. Most studies tend to agree that there is a positive correlation between controlled ovarian stimulation (COS), during which period multiple dominant follicles develop and mature to improve chances for conception, and elevated TSH levels, which are believed by some experts to have adverse effects on ART outcomes. Poppe et al [1] showed that serum TSH levels significantly and immediately increased after COS in patients receiving help from ART, and TSH levels had normalized during the follow-up period. This study observed a higher clinical pregnancy rate when basal TSH levels were less than 2.5 mIU/L. Based on a population of more than eighteen thousand pregnant women in China, Chen et al [4] clarified that high TSH levels preconception were associated with a small but significantly increased risk for overall adverse events, even within the normal nonpregnant range, and concluded that TSH < 2.5 mIU/L was more suitable for the assessment of women planning for a pregnancy
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