Intrauterine injection of human chorionic gonadotropin before embryo transfer may improve clinical pregnancy and implantation rates in blastocysts transfers

Abstract

ObjectiveTo assess the effectiveness of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer to improve implantation and clinical pregnancy rates in women undergoing transfer of blastocysts derived from fresh donor oocytes.DesignRandomized and controlled study.Materials and MethodsBetween January and December 2012, we selected 44 women undergoing endometrial preparation for transfer of blastocysts derived from fresh donor oocytes. A computer-based randomization was used to allocate the patients to two groups on the day of embryo transfer. The inclusion criteria were endometrial thickness >7mm on the day which the donor received hCG and at least two blastocist on the day of embryo transfer. In group I (n=22), they were submitted to an intrauterine injection of 500 IU of hCG 6 hours before the embryo transfer. In group 2 (n=22), women were forwarded straight to embryo transfer. The evaluated outcomes were pregnancy, clinical pregnancy and implantation rates, compared using chi-square or Fisher's exact test.ResultsIn the group of women which received intrauterine injection of hCG, we observed an increase in implantation rate (61.3% vs. 35.2%), pregnancy rate (84.4% vs 68.2%) and clinical pregnancy rate (81.8% vs 63.3%) compared to the group without hCG. The results had no statistical significance, probably due to a small number of cases.ConclusionIntrauterine hCG injection before embryo transfer seems to improve the implantation and clinical pregnancy rates in transfers of blastocysts derived from fresh donor oocytes. Nevertheless, larger researches must be performed to confirm the efficacy of this adjuvant therapy. ObjectiveTo assess the effectiveness of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer to improve implantation and clinical pregnancy rates in women undergoing transfer of blastocysts derived from fresh donor oocytes. To assess the effectiveness of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer to improve implantation and clinical pregnancy rates in women undergoing transfer of blastocysts derived from fresh donor oocytes. DesignRandomized and controlled study. Randomized and controlled study. Materials and MethodsBetween January and December 2012, we selected 44 women undergoing endometrial preparation for transfer of blastocysts derived from fresh donor oocytes. A computer-based randomization was used to allocate the patients to two groups on the day of embryo transfer. The inclusion criteria were endometrial thickness >7mm on the day which the donor received hCG and at least two blastocist on the day of embryo transfer. In group I (n=22), they were submitted to an intrauterine injection of 500 IU of hCG 6 hours before the embryo transfer. In group 2 (n=22), women were forwarded straight to embryo transfer. The evaluated outcomes were pregnancy, clinical pregnancy and implantation rates, compared using chi-square or Fisher's exact test. Between January and December 2012, we selected 44 women undergoing endometrial preparation for transfer of blastocysts derived from fresh donor oocytes. A computer-based randomization was used to allocate the patients to two groups on the day of embryo transfer. The inclusion criteria were endometrial thickness >7mm on the day which the donor received hCG and at least two blastocist on the day of embryo transfer. In group I (n=22), they were submitted to an intrauterine injection of 500 IU of hCG 6 hours before the embryo transfer. In group 2 (n=22), women were forwarded straight to embryo transfer. The evaluated outcomes were pregnancy, clinical pregnancy and implantation rates, compared using chi-square or Fisher's exact test. ResultsIn the group of women which received intrauterine injection of hCG, we observed an increase in implantation rate (61.3% vs. 35.2%), pregnancy rate (84.4% vs 68.2%) and clinical pregnancy rate (81.8% vs 63.3%) compared to the group without hCG. The results had no statistical significance, probably due to a small number of cases. In the group of women which received intrauterine injection of hCG, we observed an increase in implantation rate (61.3% vs. 35.2%), pregnancy rate (84.4% vs 68.2%) and clinical pregnancy rate (81.8% vs 63.3%) compared to the group without hCG. The results had no statistical significance, probably due to a small number of cases. ConclusionIntrauterine hCG injection before embryo transfer seems to improve the implantation and clinical pregnancy rates in transfers of blastocysts derived from fresh donor oocytes. Nevertheless, larger researches must be performed to confirm the efficacy of this adjuvant therapy. Intrauterine hCG injection before embryo transfer seems to improve the implantation and clinical pregnancy rates in transfers of blastocysts derived from fresh donor oocytes. Nevertheless, larger researches must be performed to confirm the efficacy of this adjuvant therapy.