Abstract
Background: Diabetes mellitus and atherosclerosis are significant contributors to global morbidity and mortality, with their prevalence escalating alongside the increasing incidence of obesity and sedentary lifestyles. Traditional therapeutic approaches have had limited success in fully managing these conditions, prompting interest in natural compounds such as capsaicin and gingerol. These compounds have been identified for their potential therapeutic effects, including anti-inflammatory, antioxidant, and metabolic regulatory properties. Objective: This review aims to critically assess the impact of capsaicin and gingerol on the management of diabetes and atherosclerosis, highlighting their mechanisms of action, therapeutic potential, and clinical applications. Methods: A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, Web of Science, and Google Scholar, focusing on studies that evaluated the effects of capsaicin and gingerol on diabetes and atherosclerosis. The search strategy incorporated a combination of keywords and MeSH terms related to the compounds and diseases of interest. Studies were selected based on predefined inclusion and exclusion criteria, with data extraction and quality assessment conducted according to standardized protocols. Results: The review synthesized evidence from both animal models and human clinical trials, demonstrating that capsaicin and gingerol exhibit significant potential in improving metabolic health, reducing inflammation, and mitigating the risk factors associated with diabetes and atherosclerosis. Capsaicin was found to enhance weight management and cardiovascular health through mechanisms involving the sympathetic nervous system and TRPV1 activation. Gingerol showed potent anti-inflammatory effects and improved glucose and lipid metabolism. However, the clinical applicability of these findings requires further investigation to determine optimal dosages and long-term effects. Conclusion: Capsaicin and gingerol present promising natural therapeutic options for the management of diabetes and atherosclerosis, with potential benefits extending beyond traditional treatment modalities. Further clinical trials are necessary to fully elucidate their therapeutic potential and integrate them into clinical practice.
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