Abstract
Insulin-like growth factors (IGFs) is known as peptides with important metabolic effects required for cellular growth and metabolism. IGF-I is synthesized in liver tissue under control of growth hormone (GH) and released to blood. In the process of GH to accelerate growth, IGF-I occupies a large place. IGF-I clearly showed its important effects on the growth of animal studies. In this study, the IGF-I genes of sheep were amplified by polymerase chain reaction (PCR) in sheep breeds (Akkaraman, Kivircik, Awassi, Sakiz, Daglıc, Morkaraman, Malya Karayaka (15 to 20 sheep per breed)) reared in Turkey. Informative restriction fragment length polymorphisms (RFLPs) were obtained with HaeII enzyme. The digestion of IGF-I gene with Hae II produced two alleles and three genotypes. Genotype frequencies were 59%, 19%and 22% for AA, BB and AB genotypes, respectively. Alleles frequencies were 0.70 for A allele and 0.30 for B allele. This study indicates the genetic profiles of the IGF-1 gene in native Turkish sheep breeds.
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