Abstract
Objective To explore the hypoglycemic effects of Viola tianshanica Maxim. Methods Extraction conditions by orthogonal design research, in total flavonoids as index by reflux extraction for Viola tianshanica Maxim extracted.Established mouse model of diabetes with streptozotocin(STZ), reused Viola tianshanica Maxim extract for hypoglycemic experiment.The mice were divided into high dose group, middle dosage group, low dose group, blank control group, positive control group and normal mice group, 15 mice in each group.The mice blood glucose and body weight of the different groups were observed. Results Viola tianshanica Maxim in a high concentration had significantly hypoglycemic effect in diabetic mice, average blood glucose level decreased from (18.4±5.8)mmol/L to (11.6±3.4)mmol/L, and the concentration of the extract could reduce the level of blood glucose in diabetic mice, average blood glucose level decreased from (24.8±5.6)mmol/L to (18.5±4.6)mmol/L, the differences were statistically significant(all P<0.05). Conclusion Viola tianshanica Maxim crude extract has a certain hypoglycemic effect. Key words: Violaceae; Flavones; Hypoglycins
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