Abstract
Cerebrospinal Fluid (CSF) analysis acquired a great role in the 1990’s when applied to Multiple Sclerosis (MS) diagnostic work-up. The “watery fluid” by Andreas Vesalius remained unstudied till the introduction of Lumbar Puncture (LP) at the eighteenth century. Technical developments exploded in the 1990’s: when new applications to the CSF analysis opened to the hypothesis of MS as the model of intrathecal synthesis of immunoglobulins.
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