Progress in Multiple Sclerosis Research

Abstract

Experimental Models in Demyelinating Disease.- Applications of Chronic Relapsing Experimental Allergic Encephalomyelitis to the Study of Multiple Sclerosis..- Chronic Relapsing EAE: Its Application to Study of Human Inflammatory Demyelinating Diseases..- Refinement of the EAE Model Utilizing Various Synthetic Adjuvants and Bacterial Fractions: An Attempt to Produce a Chronic Model of EAE..- Discussion.- Theiler's Virus Infection of the Central Nervous System of Mice: An Animal Model of Virus-Induced Demyelination..- Acute and Recurrent Demyelination Induced by Wild-Type and Temperature-Sensitive Mutants of Mouse Hepatitis Virus. Electron-Microscopic Studies..- Coronavirus Infection in Rats..- Search for Viral Nucleic Acids in Multiple Sclerosis Brain..- A Possible Coronavirus Isolation from Multiple Sclerosis Autopsy Material..- Defective Viral Infection: The Rescue of Virus from Antigen-Negative Cells..- Some Properties of Cortical Nerve Cells of Adult Rats Bulk Isolated After Brain Perfusion..- In Vitro Demyelination by Lymphocytes and Lymphokines from Patients and Experimental Animals..- The Virus-Host Relationship in CNS Model Cells..- Attempts to Transmit Multiple Sclerosis to Newborn and Germ-Free Nonhuman Primates: A Ten Year Interim Report..- Laboratory Investigations in Relation to the Etiology and Pathogenesis of MS.- Production of Interspecies Hybridomas Between CSF or Blood Lymphocytes from Patients with Neurological Diseases and Mouse Myeloma Cells..- Antibodies to Myelin Basic Protein in Cerebrospinal Fluid of Patients with Multiple Sclerosis..- Multiple Sclerosis De Novo Central Nervous System IgG Synthesis: Measurement, Antibody Profile, Significance, Eradication, and Problems..- Evaluation of the Blood/CSF Permeability Coefficients and of the Intrathecal Synthesis of IgG by Capillary Isotachophoresis..- CSF-Oligoclonal Bands in Multiple Sclerosis..- CSF Findings in Patients with Multiple Sclerosis and Optic Neuritis..- Oligoclonal Cerebrospinal Fluid Immunoglobulin in Relation to Measles and Parainfluenza Antibody Response in Multiple Sclerosis..- Oligoclonal Bands in Cerebrospinal Fluid..- Quantitative Determination of IgG Subclasses in CSF and Serum of MS Patients: Comparison with Other Neurological Diseases and Normal Controls..- Assessment of Process Activity in Multiple Sclerosis and Changes in Spinal Fluid..- Evaluation of IgG Synthesis in the Central Nervous System..- CSF Lipids in Demyelinating Diseases..- Diagnostic Value of Myelin Basic Protein in Cerebrospinal Fluid..- Myelin Basic Protein in Cerebrospinal Fluid as an Indicator of MS Process Activity..- Central and Peripheral Myelin Basic Protein in Cerebrospinal Fluid of Multiple Sclerosis and Other Neurological Disorders..- The Activity of a Cholesterol Ester Hydrolase in Human Cerebrospinal Fluid.- Clinical Relevance of the Determination of IgM in the Cerebrospinal Fluid with Special Reference to Multiple Sclerosis Patients..- Discussion.- Nucleic and Viral Antibodies in Serum and CSF of MS Patients..- CSF Proteinase Inhibitors..- The Occurrence of Immune Complexes in Patients with Multiple Sclerosis..- Immune Complexes in Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis..- Viral-Induced Immunological Incompetence as an Etiologic Factor in Multiple Sclerosis..- Discussion.- Approaches to Understanding the Role of Antibody in Multiple Sclerosis..- Partial Purification of MS-Specific Antigens..- Discussion.- Studies of Immune Reactions in Multiple Sclerosis by Active T-Rosette Test, Immunofixation and Myelinotoxicity of Lymphocytes in the Rabbit Eye..- Antibody-Dependent Cytotoxicity of Lymphocytes Against Basic Protein of Myelin in Multiple Sclerosis..- New Aspects of Lymphocyte Reactivity and Lymphokine Activity in Multiple Sclerosis..- Viral Antibody Responses in the Central Nervous System of Patients with Multiple Sclerosis..- Measles Reactivity in Patients with Multiple Sclerosis..- Measles Virus Infection of Human Lymphocytes..- Kinetics of Measles Virus Antibodies in Multiple Sclerosis Patients in Correlation to the Clinical Course of the Disease..- Longitudinal Studies of Viral Antibody Synthesis in MS Patients..- Discussion.- Supressor Lymphocyte Function During Attacks of Multiple Sclerosis..- Discussion.- Purification and Characterization of the T-Cell Antigen Receptor Recognizing the Basic Encephalitogenic Protein..- Immunological Cell Surface Marker Analysis in Multiple Sclerosis..- The Enhancing Effect of Multiple Sclerosis Brain Homogenates on Active E-Rosette Forming Lymphocytes in Neurological Disorders. Relationship Between Rosette Formation and Clinical Parameters..- Recent Methods of in Vitro Diagnosis of Multiple Sclerosis..- Discussion.- Distribution of Lymphocyte Subpopulations in the Peripheral Blood of MS Patients Under Corticotrophin Therapy..- Cytological Findings in Cerebrospinal Fluid as Criteria of Process Activity in Multiple Sclerosis..- Discussion.- Multiple Sclerosis: Presence of Lymphatic Capillaries and Lymphoid Tissue in the Brain and Spinal Cord..- A Histological and Histochemical Study of the Macroscopically Normal White Matter in Multiple Sclerosis..- The Pathology of the Active Lesion..- Discussion.- Glia Cell Alterations in Multiple Sclerosis..- Ultrastructural Changes in Peripheral Nerves in Multiple Sclerosis and Subacute Sclerosing Panencephalitis..- c-AMPase and Lipids in Multiple Sclerosis and Normal Brain Myelin..- Recent Trends in MS Therapy -Reports on Results.- Long-Term Immunosuppressive Treatment with Azathioprine in Multiple Sclerosis. A 10 Year Trial with 77 Patients..- Long-Term Treatment of Multiple Sclerosis with Azathioprine..- Long-Term Azathioprine Therapy in Multiple Sclerosis..- Azathioprine in Multiple Sclerosis. A Controlled Prospective Study..- Prognostic Factors in Intensive Immunosuppressive Treatment of Chronic Progressive MS..- Intensive Immunosuppression with Cyclophosphamide in Remittent Forms of Multiple Sclerosis. A Follow-Up of 134 Patients for 2-10 Years..- A Pilot Study of Amantadine Treatment of Multiple Sclerosis..- Discussion.- A Synthetic Copolymer of Amino Acids in a Clinical Trial for MS Therapy.- Studies on Myelin Basic Protein Administration in Multiple Sclerosis Patients. 1. Rationale and Preliminary Report of Immunologic Observations..- Studies on Myelin Basic Protein Administration in Multiple Sclerosis Patients. 2. Preliminary Report of Clinical Observations..- Discussion.- Essential Fatty Acids and Immunity..- Discussion.- The Effect of Diet on Serum Linoleic Acid in MS..- Metabolism of Myelin-Typical Long-Chain Fatty Acids..- Observations in 166 Patients with Multiple Sclerosis After Thymectomy..- Discussion.- Epidemiology of MS.- Correlation of the Course of MS and Histocompatibility Antigens..- HLA Patterns in Multiple Sclerosis..- Multiple Sclerosis Among Immigrants to Britain and in the Islands of Sicily and Malta..- The HLA-D System in Multiple Sclerosis..- HLA-Dw2-Associated C2 Hypocomplementemia in Multiple Sclerosis: A New Genetic Marker?.- A Sib-Pair Double-Case Study of the Genetics of Multiple Sclerosis. An Interim Report on 34 Pairs of Affected Siblings..- Discussion.- The Geographic Distribution of Multiple Sclerosis: New Concepts..- Epidemiological and Immunogenetic Studies of Multiple Sclerosis in Japan.- Cerebrospinal Fluid Findings in Japanese Patients with Multiple Sclerosis..- HLA Groups in Relation to Epidemiology..- Clustering and Epidemic Occurrence of MS..- Discussion.- Epidemiological and Serological Findings in Multiple Sclerosis, Results of a 12-Year Study in Southern Lower Saxony..- Studies on the Course of Multiple Sclerosis..- MS in Switzerland-Canton Wallis..- Epidemiological Research in MS in Italy and Optic Neuritic Risk Cases of MS..- Optic Neuritis in Hannover - An Epidemiologic and Serogenetic Study..- Some Features of MS in Pecs, Hungary..- Discussion.- Clinical Definition and Assessment of the Course of MS.- IMAB - Enquete Concerning the Diagnostic Criteria for MS..- The Role of Evoked Potentials in the Diagnosis of Multiple Sclerosis..- Value of the Evoked Potential Examination in Diagnosis of MS..- Pattern-Evoked Visual Potentials in 251 MS Patients in Relation to Opthalmological Findings and Diagnostic Classification..- Pattern and Flash Visual-Evoked Responses in Multiple Sclerosis..- Quantitative Evaluation of Visual Disturbance in Optic Neuritis. A Follow-up Study of 30 Cases by Static Perimetry..- Evaluation of Motor Deficits in Patients Suffering from Multiple Sclerosis..- CT Scan in the Diagnosis and Assessment of the Course of MS..- Quantitation and Assessment of the Course of Multiple Sclerosis. Some Remarks..- Multiple Sclerosis Clinical Trials: A Comprehensive System for the Measurement and Evaluation of Neurologic Function..- Clinicopathological and Epidemiological Documentation of Patients with Multiple Sclerosis..- Taxonomy and Multiple Sclerosis..- Discussion.- Multiple Sclerosis: Generating Effective Human Services..- Summary and Concluding Remarks..- Panel Discussion.