Abstract
The Hannover Unified Biobank (HUB) was established in 2012 as the central biobank of the Hannover Medical School (MHH) to provide an infrastructure for the standardised collection and storage of liquid biosamples and associated data in the context of research projects and clinical studies. For the comprehensive collection of tissue samples from the clinical routine the HUB cooperates with the MHH Institute of Pathology. All samples are connected with the associated clinical data stored in the ECRDW (Enterprise Clinical Research Data Warehouse) of the MHH. Headed by Prof. Dr. Thomas Illig the HUB developed into one of the biggest state of the art clinical biobanks in Germany and today stores about 2.88 Mio samples (mainly FFPE tissue and blood derived liquid samples) of a wide range of diseases.
Highlights
(2) METHODSProcessing and documentation of tissue samples was covered all over the by the Institute for pathology SOPs. In addition, as member of the German Biobank Alliance (GBA), the Hannover Unified Biobank (HUB) comply with the GBA quality standard [14] which is based on the new ISO Standard 20387 for biobanking and was developed to prepare biobanks for the ISO 20387 accreditation
German clinics the MHH was placed on rank 5 [1]
Since 2017, the Hannover Unified Biobank (HUB) is a member of the German Biobank Alliance (GBA) [9, 10] and is connected to the German Biobank Node (GBN) and BBMRI-ERIC IT network including the registration in the BBMRI Directory
Summary
Processing and documentation of tissue samples was covered all over the by the Institute for pathology SOPs. In addition, as member of the German Biobank Alliance (GBA), the HUB comply with the GBA quality standard [14] which is based on the new ISO Standard 20387 for biobanking and was developed to prepare biobanks for the ISO 20387 accreditation. The third use case is storage of the HUB basic dataset in the BIMS and clinical/patient data in external study systems. The last use case complies with data protection by pseudonymization and is supported by the biobank team by setting up customized, web based sample capture and data entry forms (eCRFs) per project in CentraXX This enables researches to set up a seamless process from sample collection and data entry over storing to retrieval and analysis. Detailed pathologic descriptions and diagnoses are available from each tissue sample, in a considerable proportion of samples immunohistochemical and molecular profiles have been documented
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