Abstract
Diabetes mellitus, following cancer and cardiovascular disease, become one of the most serious diseases that threat to human health. The treatment of diabetes is imminent for the health of people. Thus, the developments of efficient insulin administration exhibit great practical significance. The glucose-responsive insulin delivery system (GRIDS) is developing rapidly which is expected to be a promising therapy approach to replace the frequent insulin injection administration. A novel glucose-responsive nanogel was conveniently prepared through one-pot copolymerization of pentaerythritol tetra (3-mercaptopropionate), poly (ethylene glycol) diacrylate, methoxyl poly (ethylene glycol) acrylate and N-acryloyl-3-aminophenylboronic acid. The successful incorporation of phenylboronic acid (PBA) in the nanogel endowed the nanogel high glucose sensitivity in phosphate buffer saline (PBS). Therefore, the PBA incorporated nanogel with high glucose-responsiveness and good biocompatibility may have great potential for self-regulated drug release
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