The Genes Associate with Alzheimers Disease

Abstract

Alzheimer's disease (AD) is a common chronic neurological disease. In an aging society, the incidence rate is increasing year by year and remains high. Due to the decline of intelligence and cognition in patients, it is a heavy burden to the family and society. However, its pathological mechanism is not fully explained, and there is a great deal of controversy recently. Previous studies have shown that AD is characterized by the accumulation of neural plaques and neurofibrillary tangles caused by abnormal accumulation of A protein. There are also studies showing that the dysfunction of cholinergic neurons may lead to its occurrence and development. Namely, degeneration of cholinergic neurons occurs in AD and leads to alternating cognitive function and memory loss. Current treatments for AD are very limited. This situation has led to the research focus on the risk factors for the occurrence of the disease. Age, genetics and environmental factors play different roles in the development of AD. Genetic inheritance may be the basis of individual susceptibility. This article briefly introduces genetic factors and specific genes associated with AD in order to further our understanding of how this disease occurs