Abstract
Our natural product research over nine years has been to discover effective over-the-counter-supplements, designed to facilitate classical treatments in fighting disease, specifically cancer. These supplements are important in antiangiogenic, immune and antioxidant defense systems. The components include Acetyl L-Carnitine (ALC), Alpha Lipoic Acid (ALA), Coenzyme Q10 (CoQ10), Curcumin with Piperine, Genistein, Lentinan, N-Acetylcysteine (NAC), Resveratrol, selenium, Vitamin B Complex, Vitamin C, Vitamin E and zinc. These supplement components are supported for human cancer by over 15,000 references in the scientific literature withover of these being published clinical trials, not including zinc and the vitamins. These chemical defined components from natural origins have demonstrated, either individually or collectively, to have antioxidant, anti-angiogenesis, and immune stimulation properties. Furthermore, the direct cancer cell cytotoxicity for Curcumin, Genistein and NAC have been shown. Some of the antiangiogenesis components that affect the majority if not all pathways of angiogenesis, such as Curcumin, Genistein and NAC, actually stimulate the in vivo production of natural antiangiogenic compounds that include Angiostatin, Endostatin and Thrombospotin 1. All of the components play a role in serving as either water or lipid soluble (able to cross the blood-brain barrier) antioxidants. Curcumin, Genistein, Resveratrol, Lentinan, NAC, zinc, selenium and vitamins B and C all stimulate the immune system. Except for ALC and CoQ10, the other components show anti-inflammatory activity. ALC, Resveratrol along with the B and C vitamins are helpful in treating fatigue. The components that help protect the brain and promote nerve regeneration include ALA, CoQ10, Resveratrol, NAC, selenium, zinc and the B and C vitamins. In conclusion, effective prevention and treatment for diseases such as cancer, heart disease and immune deficiency will require multiple compounds.
Highlights
There is general acceptance that treatment of cancer using surgery with or without radiotherapy remains the first treatment modality for most cancer protocols
Et al (2009) had earlier shown significant Quality of Life (QOL) scores over 12 weeks with gastric cancer patients. Both studies concluded that the combination of Lentinan from the beginning of the chemotherapy may be an important factor for the improvement of patient QOL [118,119]
In animal models of chemotherapy-induced peripheral neuropathy (CIPN), Acetyl L-Carnitine (ALC) administration promoted the recovery of nerve conduction velocity, restored the mechanical nociceptive threshold, and induced analgesia by up-regulating the expression of type-2 metabotropic glutamate receptors in dorsal root ganglia
Summary
There is general acceptance that treatment of cancer using surgery with or without radiotherapy remains the first treatment modality for most cancer protocols. Advances in the early detection of tumors and in the use of chemotherapy and surgery for disease management have helped to enhance the overall survival of afflicted patients, major improvements in treatments for most human cancers are urgently needed. According to the National Institutes of Health, cancer care in 2010 cost $263.8 billion, including direct medical expenses as well as indirect costs due to lost productivity and early death. Uninsured patients and those from ethnic minorities are substantially more likely to be diagnosed with cancer at a later stage, when treatment can be more extensive. We have selected a number of clinical studies based on each component’s ability to modify in a positive way, one or more of the attributes of The Formulation
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call