Abstract 621: The importance of antioxidant, antiangiogenesis and immune stimulation in cancer

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Abstract In our quest over the last nine years to find comprehensive over-the- counter supplements, designed to facilitate current classical treatments in fighting diseases, include antiangiogenic, immune and antioxidant defense systems. These supplements include, in part, Acetyl L-Carnitine (ALC), Alpha Lipoic Acid (ALA), Coenzyme Q10 (CoQ10), Curcumin with Piperine, Genistein, Lentinan, N-AcetylCysteine (NAC), Resveratrol, selenium, Vitamin B Complex, Vitamin C, Vitamin E and zinc. These ingredients have been demonstrated, either individually or collectively, to have antioxidant, anti-angiogenesis, and immune stimulation and antioxidant properties. Furthermore, the scientific literature supports direct cancer cell cytotoxicity for Curcumin, Geinstein and NAC. The dietary supplement activities are supported by over 50,000 references in the scientific literature (PubMed.com) and over 150 clinical trials (clinicaltrials.gov), not including the human-cancer publications (23,000) and clinical trials (2,100) with zinc and the vitamins. From the literature there is evidence that some of the antiangiogenesis components that affect the majority if not all pathways of angiogenesis, such as Curcumin, Genistein and NAC, actually stimulate the in vivo production of natural antiangiogenic compounds that include Angiostatin, Endostatin and Thrombospotin 1. All of the components play a role in serving as either water or lipid soluble (able to cross the blood-brain barrier) antioxidants. Curcumin, Genistein, Resveratrol, Lentinen, NAC, zinc, selenium and the B and C vitamins all stimulate the immune system. Except for ALC and CoQ10, the other components show anti-inflammatory activity. ALC, Resveratrol along with the B and C vitamins are helpful in treating fatigue. The components that help protect the brain and promote nerve regeneration include ALA, CoQ10, Resveratrol, NAC, selenium, zinc and the B/C vitamins. In conclusion, effective prevention and treatment from and for diseases such as cancer, heart disease and immune deficiency will require multiple compounds. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 621. doi:1538-7445.AM2012-621