Abstract
Objective To investigate the expression level of AFP-IgM in hepatocellular carcinoma (HCC).Methods The serum AFP-IgM concentrations were detected by ELISA in 79 HCC patients,20 patients affected by liver cirrhosis and 30 healthy controls.Results AFP-IgM concentrations in serum and the positive rate were significantly higher in HCC than that in liver cirrhosis and in healthy controls(P＜0.01).The positive rates of AFP-IgM in the stage Ⅰ or Ⅱ(89%,88%)were higher than that of the stage Ⅲ(30%,P＜0.05).The serum concentration of AFP-IgM is related to the stage,tumor sizes.Conclusion AFP-IgM was of significance for early diagnosis of HCC,it will hopefully be a useful biological marker for the diagnosis of HCC. Key words: Hepatocellular carcinoma; Alpha-fetoproteins; Immunoglobulin M
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