Abstract

目的 总结先天梅毒患儿在临床表现和血清、脑脊液梅毒抗体方面的特点.方法对40例先天梅毒患儿进行了临床特点和血清、脑脊液梅毒抗体的分析.结果 40例先天梅毒患儿中出现皮疹的有14例(35%),有骨损害表现的6例(15%);由于母亲患梅毒而就诊的16例(40%),40例先天梅毒患儿中,快速血浆反应素试验(RPR)阳性33例(82.5%),阳性血清RPR滴度介于1∶1~1∶64之间,2例RPR异常增高,滴度为1∶128.患儿脑脊液常规检查显示,45%淋巴细胞增高,50%蛋白增多,22.5%的患儿脑脊液存在梅毒抗体.性病研究实验室试验(VDRL)和梅系螺旋体被动颗粒凝集试验(TPPA)相比,检出率差异有显著意义(P<0.05). 结论必须重视先天梅毒患儿神经梅毒的发生,脑脊液梅毒抗体检测对正确评价病情和指导治疗有重要意义。

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