The energetics of solvation and ion-ion interactions in prospidium chloride aqueous solutions

Abstract

This paper focuses on the first accurate thermochemical study of hydration and interactions of the well-established cytostatics “Prospidine” (prospidium chloride) in water. Enthalpies of solution of the drug have been determined with the isoperibol solution calorimeter at 298 and 313 K and heat capacities of solid prospidine have been obtained with the NETZSCH DSC calorimeter at 275–355 K. Standard enthalpies and heat capacities of solution, partial molal heat capacities at an infinite dilution as well as enthalpic parameters of solute-solute pair interactions have been computed using the Redlich-Rosenfeld-Meyer-type equation and discussed in terms of solute-solvent and solute-solute interactions in a liquid phase.