Abstract
The Elucidation of the Structure of Ribonuclease by Stanford Moore and William H. Stein
Highlights
A previous Journal of Biological Chemistry (JBC) Classic [1] on Stanford Moore (1913–1982) and William H
Stein (1911–1980) offered a look into their early careers, including their development of chromatographic methods for determining protein composition, their invention of the photoelectric drop-counting fraction collector, and their creation of the first amino acid analyzer. This Classic focuses on their elucidation of the amino acid sequence of pancreatic ribonuclease, its disulfide bonds and active site residues
By repeating this experiment with chymotrypsin and pepsin they were able to deduce the sequence of the entire protein, which is published in the first JBC Classic reprinted here
Summary
A previous Journal of Biological Chemistry (JBC) Classic [1] on Stanford Moore (1913–1982) and William H. The Elucidation of the Structure of Ribonuclease by Stanford Moore and William H. The Sequence of the Amino Acid Residues in Performic Acid-oxidized Ribonuclease Alkylation and Identification of the Histidine Residues at the Active Site of Ribonuclease
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