The efficacy of sodium ozagrel in the treatment of ischemic stroke

Abstract

Objective To explore the efficacy of sodium ozagrel for ischemic stroke. Methods 54 patients with ischemic stroke who had been hospitalized during the period of January 2010 to February 2011 were randomly assigned to receive sodium ozagrel (27 patients, study group ) oraSpirin (27 patients, control group ). The scores on NIHSS and the efficacy were assessed in the two groups before and 14 days after treatment. Results There was a statistical difference in the total effective rate between the two groups ( 85.19% in the study group vs. 48.15% in the control group, P < 0.05 ). 14 days after treatment, the scores on NIHSS were markedly lower in both groups and the scores in the study group were superior to those in the control group ( P < 0.05 and P < 0.01 ). The plasma concetration, platelet aggregation ratio, fibrinogen content, and prothrombin time differed significantly 14 days after treatment ( P < 0.05 ). Conclusions The therapy with sodium ozagrel for ischemic stroke is effective, has fewer adverse reactions, and is worth popularizing. Key words: Ischemic stroke; Sodium ozagrel; Efficacy