Berberine hydrochloride combined with sodium ozagrel in the treatment of acute cerebral infarction and its effect on glucose and lipid metabolism

Abstract

Objective To investigate the effects of sodium ozagrel and berberine hydrochloride in the treatment of acute cerebral infarction and its effect on glucose and lipid metabolism. Methods According to the digital table, 158 patients with acute cerebral infarction were randomly divided into the two groups: the control group was treated with the sodium ozagrel group and the observation group was treated combined with sodium ozagrel and berberine hydrochloride. After 2 weeks, Chinese stroke clinical neural function defect score scale and the National Institutes of Health Stroke Scale(NIHSS)was used to evaluate neurological function. The therapeutic effectiveness was assessed by ADL after treatment 1,3,6 months. The changes of glucose and lipid levels were detected by turbidimetric method. Results The total effective ratein the observation group was obviously higher than that of the control group(87.01%vs 69.14%)(χ2=7.316,P 0.05).After the treatment,the fasting blood glucose level was reduced significantly in the observation group(t=0.859,P 0.05). Conclusion The therapeutic effect of berberine hydrochloride combined with sodium ozagrel is better in the treatment of acute cerebral infarction, and the level of glucose and lipid metabolism was significantly decreased. Key words: Brain Infarction; Berberine; Sodium Ozagrel