Abstract
Extensive chemical modification and biological testing of benzenesulphonamides resulted in the selection of 4-amino-6-trichloroethenyl-1,3-benzenedisulphonamide as the most promising fasciolicide in this series. Dosages of 10 and 15 mg/kg were 97 and 92% effective against immature liver flukes in calves and sheep respectively. Mature flukes in both sheep and cattle were removed by a single dose of 3 · 75 mg/kg.
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