Abstract
A 100 litter of pharmaceutical formula of veterinary drug Rafoxanide and Levamisole with 6% suspension as pilot production was prepared. The formula contains two active ingredients with a broad spectrum anthelmintic activity. Rafoxanide belong belongs to salicylanilide group used for treatment and control of mature and immature liver flukes in cattle, sheep and goats. Levamisole belongs to Bezimidazole compounds and is active against gastrointestinal worms and against lung worms in cattle, sheep and goats. The drug formula is a white color suspension prepared according to scientific literature. Information was collected for all substances in the formulation for active ingredient ingredients and additives. The chemical assay was carried out on the active ingredients and the final formula and the results showed that they conform to the constitutional specifications. The results of the chemical assay of Rafoxanide (102.7%) and levamisole (101%) were found to be within the approved constitutional limits (90-110%) with the adoption of the results of stability study at temperatures (40, 50, 60 °C). The stability of the pharmaceutical formula was observed within the permissible constitutional limits.
Highlights
Rafoxanide belong belongs to salicylanilide group used for treatment and control of mature and immature liver flukes in cattle, sheep and goats
The chemical assay was carried out on the active ingredients and the final formula and the results showed that they conform to the constitutional specifications
The results of the chemical assay of Rafoxanide (102.7%) and levamisole (101%) were found to be within the approved constitutional limits (90-110%) with the adoption of the results of stability study at temperatures (40, 50, 60 °C)
Summary
The pharmaceutical formula of the suspension consisted of two broad-spectrum anthelmintics: 1. Rafoxanide belongs to the halogenated salicylanilide group, which affects on the parasite by inhibiting the synthesis of adenosine triphosphate (ATP). Rafoxanide belongs to the halogenated salicylanilide group, which affects on the parasite by inhibiting the synthesis of adenosine triphosphate (ATP). It is strongly associated with blood proteins and has long effect in has a long effect on the blood. Rafoxanide is a white - gray powder It is insoluble in water, soluble in 25 part of acetone, in 40 part of chloroform, 35 part of ethyl acetate, slightly soluble in methanol [6]. 2. Levamisole belongs to the Imidazolthiazole derivative group, which is rapidly absorbed from the gastrointestinal tract and is metabolized in the liver and excretion from the body by the kidneys (70% within 3 days).
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