Abstract
Candida albicans is the most usually isolated species in invasive oral candidiasis, which is a major health concern in underdeveloped nations. So pyocyanin was screened in Pseudomonas aeruginosa and found that the highest level of productivity in King A medium appeared compared with cetrimide agar, also, the productivity was increased in presence of sweet potato in comparison with soya bean. The pyocyanin was purifi ed with silica gel chromatography as a single peak with high purity. C. albicans causing oral candidiasis is considered a stronger producer of biofi lms. The eff ect of pyocyanin on Candida biofi lm formation was inhibited with increasing incubation concentration and with increasing incubation period and the percentage of biofi lm inhibition reached 73–87% after 72 hours.
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