Abstract
Objectives. In current study, the relationships between serum vitamin D3 levels and serum UA concentrations as well as their interaction with severity of PD were evaluated in a sample of Iranian PD patients. Method. In a cross sectional study at the one of the main referral hospitals in central region of Iran, during September to November 2011, 112 patients were recruited. Severity of PD was evaluated sing H&R stages and UPDRS. Results. The Spearman rank correlation coefficient suggests the negative significant association between serum vitamin D3 and UPDRS in patients aged >62 (r = −0.34, P < 0.05). No statistically significant association was observed between the UA levels and severity of PD (represented by H&Y categories) in different levels of serum vitamin D3 not only in total sample but also in separate age and sex groups. The linear regression coefficients suggested positive association between UA and serum vitamin D3 with UPDRSIII scores while negative relationship between UA and serum vitamin D3 interaction with UPDRSIII; however it was only statistically significant in age group ≤62 (P < 0.05). Conclusion. Our study revealed a negative correlation between interaction of serum vitamin D3 and UA with severity of PD; other studies are required to confirm our findings.
Highlights
Parkinson disease (PD) is a common neurodegenerative disorder, characterized by motor dysfunctions including rest tremor, rigidity, and bradykinesia [1, 2] which considerably impair the quality of life of the PD patients [3].PD was considered to be largely unknown and its pathogenic mechanisms remained uncertain
Positive associations were observed between Uric acid (UA) and serum vitamin D3 with severity of disease when measured by Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn and Yahr Scale (H&Y) in total study’s sample and in different age and gender groups based on simple correlation analysis; negative significant correlation was observed between serum vitamin D3 and UPDRS in patients aged above 62 years
We did not find any significant association between serum vitamin D3, serum UA concentrations, and their interaction with UPDRS and H&Y based on multiple linear and logistic regression analysis when adjustments were made for potential confounding factors such as gender, age, and disease duration
Summary
Parkinson disease (PD) is a common neurodegenerative disorder, characterized by motor dysfunctions including rest tremor, rigidity, and bradykinesia [1, 2] which considerably impair the quality of life of the PD patients [3].PD was considered to be largely unknown and its pathogenic mechanisms remained uncertain. The eight markers’ genes were significantly correlated with PD and they do not seem to be involved in a common biologic pathway or process, all are expressed in the human brain [6]. There is evidence for abnormalities in vitamin D3 and the endocrine system in patients with PD and a higher prevalence of vitamin D3 deficiency has been reported compared to age-matched healthy controls [8,9,10]. It is reported that the distribution of vitamin D3 receptors in the substantia nigra is widely known to be affected in PD and the involvement of this vitamin has Parkinson’s Disease been revealed in the regulation of tyrosine hydroxylase gene expression and dopamine biosynthesis [10, 14]. Some studies have identified that the level of serum vitamin D3 is negatively interrelated with PD severity [6, 15, 16], while some others did not confirm these results [17]
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