Abstract
The effects of tri-iodothyronine on mitochondrial protein synthesis have been studied in in vitro labeled, isolated rat hepatocytes. Hepatocytes were isolated from hypothyroid rats or from hypothyroid rats 24 h after injecting a single, low dose of hormone (20–30 μg/180–230 g body weight). Triiodothyronine increased translation on mitochondrial ribosomes by 2–3-fold, but, under our conditions, appears to have little or no effect on the general synthesis of cytoplasmically-translated mitochondrial proteins. Electrophoretic and fluorographic analysis indicated that tri-iodothyronine stimulates labeling of the four major mitochondrially-translated peptides. The hormone appears to act by inducing a general increase in translation/transcription of mitochondrially-synthesized peptides.
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