The effects of Telbivudine for the prevention of perinatal transmission of hepatitis B virus infection from pregnant women to newborn on the expression of IL-17A,IL-10,IL-6 in the maternal plasma,umbilical plasma,neonatal plasma

Abstract

Objective To explore the expression of interleukin-17A(IL-17A),interleukin-10(IL-10),interleukin-6(IL-6)in the maternal plasma,umbilical plasma,neonatal plasma from the pregnant women who accepted the Telbivudine for the prevention of perinatal transmission of hepatitis B virus infection. Methods 85 pregnant women who were delivered in the hospital were chosen[Telbivudine group 25 cases,HBVDNA high viral level group,HBVDNA negative group,non-infection group(health pregnant),each group included 20 cases].The level of the serum of IL-17A,IL-10,IL-6 in the maternal plasma,umbilical plasma,neonatal plasma from the different group was prospectively analyzed by the CBA method. Results The levels of IL-17A in the maternal plasma,umbilical plasma,neonatal plasma of the Telbivudine group[(15.29±4.80)pg/ m L,(19.45±4.80)pg/m L,(17.32±4.18)pg/m L]were lower than the HBVDNA high viral level group[(26.03±4.88)pg/m L,(34.07±5.59)pg/m L,(24.12±4.76)pg/m L],there were significant differences(P= 0.000, 0.001,0.019);The level of IL-10 in the maternal plasma,umbilical plasma,neonatal plasma of the Telbivudine group[(6.08±1.32)pg/m L,(2.33±0.68)pg/m L,(3.74±0.61)pg/m L]were higher than the HBVDNA high viral level group[(3.95±1.21)pg/m L,(1.71±0.53)pg/m L,(2.22±0.55)pg/m L],there were significant differences(P= 0.023,0.015,0.012);The level of IL-6 in the maternal plasma,umbilical plasma,neonatal plasma of the Telbivudine group were lower than the HBVDNA high viral level group,there were significant differences(all P<0.05). Conclusion Telbivudine can cause the inhibition of the replication of HBV virus,partially reverse the immunologic dissonance of the pregnant women with HBV virus,which is conducive to maintaining pregnancy. Key words: Hepatitis Brirus; Interleukins; Telbivudine