Abstract
Background. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. Methods. Ten Wistar rats in each group were topically given base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% Punica granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content in P. granatum extract was determined. Results. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containing P. granatum extract than in rats treated with cream containing SSD (2.8 ± 0.9 cm2 versus 8.4 ± 3.2 cm2). The wounds completely healed on day 25 of the treatment in rats treated with creams containing P. granatum flower extract compared with those in rats treated with the other agents. Conclusion. These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries.
Highlights
Burn injury is a public health problem worldwide, especially in undeveloped countries that lack adequate medical facilities, in terms of morbidity, long-term disability, and mortality [1, 2]
These results indicated that wound healing in rats treated with P. granatum flower extract occurred 10 days before that in rats treated with the other agents
The results of this study showed that creams containing 5% and 10% P. granatum flower extract facilitated the healing of the burned tissue
Summary
Burn injury is a public health problem worldwide, especially in undeveloped countries that lack adequate medical facilities, in terms of morbidity, long-term disability, and mortality [1, 2]. Creams containing 1% silver sulfadiazine (SSD) are primarily used for treating burn injuries because of the antibacterial activity of SSD [1, 4, 9, 10]. We compared the efficacy of P. granatum (P) flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats. The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containing P. granatum extract than in rats treated with cream containing SSD (2.8 ± 0.9 cm versus 8.4 ± 3.2 cm). The wounds completely healed on day 25 of the treatment in rats treated with creams containing P. granatum flower extract compared with those in rats treated with the other agents. These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
