Abstract
This study evaluated the effect of combined inositol hexakisphosphate (IP6) and inositol supplement on organ weight, intestinal ATPase activities, complete blood count, and serum analytes in streptozotocin (STZ)-induced type 2 diabetic rats. High-fat diet and a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) were used to induce type 2 diabetes mellitus in Sprague–Dawley rats. The diabetic groups were then treated with either combined IP6 and inositol supplement or glibenclamide for four weeks. Organ weights, intestinal ATPase activities, complete blood count, serum α-amylase, total protein, albumin, and globulin content were determined. Pancreatic weight was significantly reduced while relative kidney and liver weights were elevated in the group treated with combined IP6 and inositol supplement compared to the nondiabetic control. Serum α-amylase activity for the glibenclamide and combination treated groups was significantly improved compared to that of the untreated diabetic group. Red cell distribution width percentage was significantly lower in the combination treated group compared to that in the untreated diabetic group, while intestinal ATPase activities were unaffected by the treatment regime. Combined IP6 and inositol supplement consumption may protect people with diabetes from increased risk of cardiovascular diseases due to the supplement's ability to maintain red cell distribution width percentage towards the normal control group.
Highlights
Diabetes mellitus is a chronic disorder that occurs either because of the inability of the pancreas to produce adequate amounts of insulin or its failure to utilize available insulin efficiently
The liver weight relative to body weight was significantly increased among the treated and untreated diabetic groups compared to the nondiabetic group
Kidney weight relative to body weight was significantly increased in the treated and untreated diabetic groups compared with the nondiabetic rats (p < 0.05). ere was a significant reduction in pancreatic weight among the treated and untreated diabetic groups compared with nondiabetic groups. e weights of the spleen and heart among the groups were not significantly different
Summary
Diabetes mellitus is a chronic disorder that occurs either because of the inability of the pancreas to produce adequate amounts of insulin or its failure to utilize available insulin efficiently. Morbidity and mortality among both youth and adult populations have significantly increased due to diabetes mellitus. Ere is a strong association between diabetes mellitus and an increased risk of developing cardiovascular diseases, neuropathies, and microvascular damage to organs including the kidneys and eyes. Ere are several oral hypoglycemic agents commercially available; many have undesirable side effects. Inositol hexakisphosphate (IP6 or InsP6), known as phytic acid, is a polyphosphorylated inositol derivative. Both IP6 and inositol are abundantly present in many legumes and whole grains and are present in mammalian cells. Abnormalities in inositol metabolism (inosituria and inositol intracellular depletion) have been observed in several human and animal
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