Abstract
PurposeObesity is associated with alterations in serum fatty acid profiles. One-anastomosis gastric bypass is a type of bariatric surgery used in the treatment of morbid obesity. The aim of this study was to establish if, between 6 and 9 months after this procedure, the fatty acid composition in the serum of patients normalizes to values similar to the healthy, lean population.Materials/MethodsThe study included 46 patients that underwent surgical treatment for obesity with one-anastomosis gastric bypass. The serum fatty acid composition was determined using gas chromatography-mass spectrometry. Principal component analysis was conducted to detect the differences between fatty acid profiles in patients pre- and post-surgery, and in 29 control nonobese subjects.ResultsPatients with morbid obesity were characterized by lowered levels of beneficial odd- and branched-chain fatty acids and polyunsaturated fatty acids. While the odd- and branched-chain fatty acid amounts normalized 6–9 months after bariatric treatment, the polyunsaturated fatty acid levels did not. Moreover, the total fatty acid profiles of patients pre- and post-bariatric surgery were still markedly different than those of lean, healthy controls.ConclusionFollowing one-anastomosis gastric bypass, there are some beneficial changes in serum fatty acids in treated patients, possibly due to weight loss and dietary regimen changes. However, they may be insufficient to restore the proper levels of other fatty acids, which may need to be additionally supplemented.Graphical abstract
Highlights
The myriad severe health impacts of obesity prompt the need for effective treatment
Since some groups of Fatty acids (FAs) are considered beneficial, e.g. n-3 polyunsaturated FAs (PUFAs), whereas others are adverse to human health, e.g. saturated FAs (SFAs) [10], every change in their levels may have an important effect on the metabolic outcome of a bariatric surgery
Patients with morbid obesity after Oneanastomosis gastric bypass (OAGB) exhibited a significant decrease in body mass index and fasting blood glucose concentration as well as an improvement in the levels of triglycerides, and total and LDL-cholesterol (Table 1)
Summary
Fatty acids (FAs) are primary components of almost all lipid species, and their composition, arising as the sum of endogenous synthesis and dietary intake, can provide valuable information when we consider different, sometimes even opposing effects of various FA groups on metabolism [10]. Since some groups of FAs are considered beneficial, e.g. n-3 polyunsaturated FAs (PUFAs), whereas others are adverse to human health, e.g. saturated FAs (SFAs) [10], every change in their levels may have an important effect on the metabolic outcome of a bariatric surgery. In our work, we showed that OAGB reconstitutes the appropriate serum amino acid profiles to the levels measured in nonobese, healthy people [9]. The primary aim of this study is to verify if OAGB reconstitutes the appropriate serum fatty acid profiles to the levels similar to lean, healthy people. The secondary aim is to examine the changes in individual FAs after surgery
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