The effectiveness of medical personnel vaccination against hepatitis B

Abstract

Medical personnel belong to the occupational risk group of hepatitis B virus (HBV) infection due to the increase of parenteral interventions and procedures using sophisticated equipment, constant contact with biological fluids of patients, the widespread use of antibiotics and cytostatics that have an immunosuppressive effect, etc. Insufficient objectivity in assessing the quality of hepatitis B (HBV) immunoprophylaxis only according to documentation may be associated with a violation of immunization regimens, the presence of chronic pathology in vaccinated, age-related immunodeficiency. Despite the effectiveness of HCV vaccination, the protective activity of specific humoral immunity (antibodies to HBsAg — anti-HBs) among vaccinated medical workers has not been sufficiently studied. The results of studying the intensity and duration of the immune response in 2075 employees of two large multidisciplinary hospitals vaccinated against HBV (average age 46.3 ± 10.1 years) are presented. A high level of vaccination coverage of medical personnel in hospitals No. 1 and No. 2 was established, amounting to 96.6 % and 97.2 %, and the level of collective immunity was equal to 1645.5±72.5 IU/l and 886±123.7 IU/l, respectively. The absence of cases of HBV in vaccinated individuals during immunoprophylaxis according to the standard scheme was noted. It seems advisable to use an individual approach to the tactics of revaccination when reducing the content of anti-HBs in the blood to low concentrations (10–100 IU / l), preventing them from falling below the protective level.