Abstract

Hepatitis B virus (HBV) infection is a major public health problem and cause of infectious disease mortality worldwide. Approximately 2 billion people one third of the world’s population have serologic evidence of past or present HBV infection, and 350 million people are chronically infected. Each year over 1 million people die from HBV-related chronic liver disease, including cirrhosis and hepatocellular carcinoma (HCC) (1). HCC is one of the most common cancers worldwide, and HBV is responsible for at least 75% of these cancers (2).

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