The effectiveness of complex therapy in the treatment of nonspecific vaginitis in women of reproductive age

Abstract

Objective. One of the most common gynecological pathologies among women of reproductive age is non-specific vaginitis. Bacterial vaginosis and aerobic vaginitis cause many obstetric and gynecological complications, and disease recurrence remains high. The aim of the study is to assess the effectiveness of complex therapy in the treatment of non-specific vaginitis in women of reproductive age.
 Materials and Methods. 160 women (100%) were examined, which were divided into 2 clinical groups with subgroups: the main group - 94 (58.8 %) patients with nonspecific vaginitis, who received treatment according to developed clinical diagnostic algorithms and schemes. The comparison group included 66 (41.2 %) patients with nonspecific vaginitis, who received treatment according to known protocols. Research methods: general (collection of complaints and anamnesis, gynecological examination, assessment of microscopy of vaginal smears according to the Amsel, Nugent and Donders criteria), laboratory (determination levels of follicle-stimulating, luteinizing hormones, prolactin, estradiol, adrenaline, noradrenaline, cortisol, magnesium in the blood), statistical.
 Results. Treatment of non-specific vaginitis according to complex schemes in the main group showed a significant decrease in the average follicle-stimulating hormone indicators – by 2.7 times, luteinizing hormone – by 2.6 times, prolactin – by 1.3 times (р<0,05) compares to the indicators before treatment. The estradiol level in the main group probably increased 1.3 times (р<0,05). The magnesium level also increased by an average of 1.4 times (р<0,05). Complex therapy in the main group significantly reduced the adrenaline levels by an average of 1.6 times, noradrenaline by 2.4 times, and cortisol by 1.8 times compared to the values before treatment (р<0,05). The proposed complex schemes are likely to improve the clinical effectiveness of drug treatment of non-specific vaginitis in the near and distant periods, which is accompanied by faster disappearance of complaints and normalization of the local condition during the gynecological examination (p<0,05), restoration of the vaginal microflora (p<0,05), a decrease frequency of recurrence in the main group of patients (c2=4,32; p<0,05).
 Conclusions. It is appropriate to use complex treatment of bacterial vaginosis and aerobic vaginitis in women of reproductive age.