Effects of magnesium deficiency on stress manifestations in women of reproductive age with nonspecific vaginitis

Abstract

Nonspecific vaginitis is one of the most common problems in women of reproductive age, which ranks first in the structure of gynecological diseases and tends to increase. It is known that one of the causes of nonspecific vaginitis is the chronic stress influence on a woman’s body. At the same time, not only the hormonal system changes, but there is also a deficiency of trace elements, especially magnesium. Aim. To study the effect of magnesium preparations on the clinical manifestations of stress in the complex treatment of nonspecific vaginitis in women of reproductive age. Materials and methods. 160 women were examined, who were divided into 2 clinical groups with subgroups: the main group – 94 (58.8 %) patients with nonspecific vaginitis, who received treatment according to developed clinical diagnostic algorithms and schemes. The comparison group included 66 (41.2 %) patients with nonspecific vaginitis, who received treatment according to known protocols. In the process of examining groups, the following methods of examination were used: general (collection of complaints and anamnesis, gynecological examination, assessment of microscopy of vaginal smears according to the Amsel, Nugent and Donders criteria), laboratory (serum levels of adrenaline, noradrenaline, cortisol, magnesium), questioning, statistical. Results. The use of magnesium preparation according to the scheme in the main group significantly reduced the symptoms of anxiety and depression, normalized the blood magnesium level in contrast to the comparison group (Р < 0.05). Conclusions. In women of reproductive age, suffering from nonspecific vaginitis, who are constantly under the influence of stress factors, a deterioration in the psycho-emotional state is determined in the form of anxiety and depression of varying severity, as evidenced by the results of the Hospital Anxiety and Depression Scale (HADS). In addition, in such women, there is an increase in the levels of stress hormones (adrenaline, noradrenaline, cortisol), a decrease in the blood magnesium level in contrast to the indicators in healthy individuals. The use of magnesium preparation according to the scheme in the complex treatment of nonspecific vaginitis in women of reproductive age with chronic stress normalizes the blood magnesium levels, significantly improves the psycho-emotional state, reduces the symptoms of anxiety and depression and significantly improves the direct results of treatment.