THE EFFECT OF VARIOUS VARIANTS OF ANTIARRHYTHMIC THERAPY ON THE STRUCTURAL AND FUNCTIONAL STATE OF THE LEFT VENTRICULAR MYOCARDIUM IN PATIENTS WITH ARTERIAL HYPERTENSION AND FREQUENT ATTACKS OF ATRIAL FIBRILLATION DURING 6 MONTHS OF TREATMENT

Abstract

The aim - to determine the effect of various antiarrhythmic therapy on the structural and functional state of the left ventricular myocardium in patients with arterial hypertension (AH) and frequent attacks of atrial fibrillation (AF) during 6 months of treatment.Materials and methods. There were examined 146 patients aged from 37 to 86 years with AH stage II complicated by frequent recurrences of AF. All examined patients received permanent antiarrhythmic therapy. All patients underwent echocardiography (EchoCG) according to the standard protocol at the beginning of the study and after 6 months of treatment.Results. 6-month treatment with propafenone and etatsizin, as well as a combination of etatsizin with bisoprolol in patients with AH and frequent attacks of AF without severe structural damage of the myocardium showed significant decreasing of end-diastolic dimension and end-systolic dimension of the left ventricle, left ventricular mass index, the size and the volume of the left atrium, right ventricular size, E/e' average ratio and increased left ventricular ejection fraction, and Ve/Va ratio.Conclusions. 6-month treatment with 1C class of propaphenone and etatsizin, as well as a combination of etatsizin with bisoprolol in patients with arterial hypertension and frequent attacks of atrial fibrillation without severe structural damage of the myocardium has not adversely affect on the structural and functional state of the myocardium and it is accompanied by significant decreasing of end-diastolic dimension and end-systolic dimension of the left ventricle, left ventricular mass index, the size and the volume of the left atrium, right ventricular size, ratio E/e'average and increased left ventricular ejection fraction and Ve/Va ratio.