The effect of the recombinant tissue plasminogen activator combined with reduced glutathione in the treat-ment of acute ST-elevation myocardial infarction

Abstract

Objective To investigate the effect and safety of the recombinant tissue plasminogen activator （ rt-PA） combined with reduced glutathione （ RGSH ） in the treatment of acute ST-elevation myocardial infarction （ ASTEMI） .Methods 110 cases of ASTEMI were randomly divided into the control group and the observation group,55 cases in each group.The control group was intravenously injected 50mg rt-PA once a day,while the observa-tion group was injected 1200 mg RGSH freeze-dried powder once a day based on the control group .The vascular reca-nalization rate,the changes of myocardial enzymes ,cardiac structure and function parameters before and after treat-ment and adverse reactions in two groups were compared .Results The recanalization rate of the observation group and the control group reached 92.73%and 89.09% respectively,the difference between two groups was not signifi-cant （P〉0.05）.After treatment,the levels of CK,AST,cTnT,cTnI and CK-MB in the observation group were signifi-cantly lower than those of the control group （P〈0.05）,while the level of SOD was significantly higher than the con-trol group（P〈0.05）.The LVEDd and LVESd in the observation group were （52.24 ±5.83）mm and （39.95 ± 7.06）mm respectively,which were significantly lower than those in the control group （P 〈0.05）,while the EF [（63.25 ±9.38）%] was significantly higher than that of the control group （P〈0.05）.The total adverse reaction rate in the observation group was 10.91%,which was significantly lower than 21.82% in the control group （ P〈0.05）.The reinfarction rate in the observation group was 3.63%,which was significantly lower than 12.73% in the control group（P〈0.05）.Conclusion The rt-PA routine thrombolysis therapy combined with RGSH could improve the recanalization rate and left ventricular structure and function of the ASTEMI patients and has less adverse reac -tion.The curative effect is better than single rt-PA. Key words: Acute ST-elevation myocardial infarction; Recombinant tissue plasminogen activator; Reduced glutathione