The effect of shenfu injection on immune function in severe trauma patients

Abstract

Objective To investigate the effect of shenfu injection on immune function in severe trauma patients. Methods 60 severe trauma patients were divided into the control group (n=30) and shefu group (n=30) by random number table.Other 30 cases were chosen as the health control group at the same phase.All patients were received conventional treatments, however, patients of the shenfu group were additionally received the shenfu injection treatment in the early stage.The CD3+, CD4+, CD8+ cell, human leukocyte antigen (HLA-DR), interleukin-1(IL-1), interleukin-6(IL-6) were detected on 3rd and 7th day by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results Compared to the health control group, the IL-1, IL-6 in the control and shenfu group were significantly higher than the health control group(f=7.128, q=9.212, 10.112, all P<0.05). The IL-1and IL-6 in the control and shenfu group were significantly increased on 3rd day (t=11.126, 10.013, all P<0.05) and decreased on 7th day(t=17.121, 14.213, all P<0.05). The IL-1 and IL-6 in shenfu group were significantly lower than that of the control group(χ2=4.113, 10.117, all P<0.05). The CD3+, CD4+, CD8+, HLA-DR and CD3+/CD8+ rate in the control and shenfu group were significantly lower than the health control group(f=11.071, q=10.229, 12.032, all P<0.05). On 3rd day, the CD3+, CD4+, CD8+, HLA-DR and CD3+/CD8+ rate in shenfu group were significantly increased(t=10.013, P<0.05). On 7th day, CD3+, CD4+, CD8+, HLA-DR and CD3+/CD8+ rate in the control and shenfu group were both increased(t=11.126, 15.932, all P<0.05). And the CD3+, CD4+, CD8+, HLA-DR and CD3+/CD8+ rate in shenfu group were significantly higher than the control group(χ2=3.771, P<0.05). Conclusion Shenfu injection can regulate immune function in severe trauma and improve clinical treatment. Key words: Wounds and jnjuries; Immune function; Shenfu injection