Abstract
Psoralen and isopsoralen are two isomers and main effective components within Psoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectrometric (UHPLC-MS/MS) method has been developed and validated for simultaneous determination of the 2 components in rats' tissues after administration of the extracts that came from either crude or salt-processed Psoralea corylifolia L. Data displayed that both areas under the curve (AUC) of psoralen and isopsoralen from salt-processed scurfpea fruit group were significantly increased compared with that of the crude herb group, especially in heart (p < 0.05), ovary, and testes (p < 0.001). Though the RE and RCmax of psoralen and isopsoralen in all of the investigated organs were over 1.0, generative organs kept the maximum value. The experiment manifested that salt-processing of scurfpea fruit can increase the distribution of psoralen and isopsoralen to generative organs, heart and spleen, and the distribution of psoralen and isopsoralen to generative organs is significantly higher compared to heart and spleen (p < 0.01). Results indicate that salt-processing of scurfpea fruit can significantly increase the distribution of psoralen and isopsoralen to generative organs.
Highlights
Meridian tropism theory, one of the basic theories in TCM, plays an important role to select herbs which are based on clinical syndromes [1]
Psoralea corylifolia is the fruit of Psoralea corylifolia L., which belongs to Leguminosae
The results showed that the relative uptake efficiency (RUE), relative Cmax (RCmax), and relative targeting efficiency (RTE) values in generative organs were much greater than heart and spleen, which indicated that psoralen and isopsoralen exhibited targeting effect to generative organs after salt-processing
Summary
One of the basic theories in TCM, plays an important role to select herbs which are based on clinical syndromes [1]. According to this theory, herbs have special affinities to certain organs and channel systems of the body and exhibit special effects on diseases of these systems or organs [2, 3]. Psoralea corylifolia is the fruit of Psoralea corylifolia L., which belongs to Leguminosae It was frequently been used in TCM prescription to prevent or treat various body disorders and diseases, such as osteoporosis and bone fracture [6], arthralgia, and asthma [7, 8]. More than 10 compounds were isolated from Psoralea corylifolia, such as psoralen, isopsoralen, psoralidin, bavachin, corylin, bavachalcone, and bakuchiol [9, 10]
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