Abstract
Objective: To investigate the effect of mesalazine on Ulcerative Colitis (UC) in male mice model. Method: Male mice aged 6-8 weeks were selected and randomly divided into Dextran Sodium Sulfate group (DSS group), mesalazine group (Tr group), and Control group (Con group). During the experiment, observe the body weight, stool characteristics, occult blood, changes in mice hair, eating habits and activity status, etc. After euthanizing the mice, eyeball blood was taken to measure IL-6 and TNF-α, and Disease Activity Index (DAI) was calculated. Take colon tissue (from the end of the cecum to the anal segment) and measure its length, and make paraffin sections, and observe them under a microscope after HE staining, and calculate their histopathological scores.
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