The Effect of Liver Therapy on the Neurologic Aspects of Pernicious Anemia

Abstract

Article1 May 1933The Effect of Liver Therapy on the Neurologic Aspects of Pernicious AnemiaPAUL H. GARVEY, M.D., PAUL M. LEVIN, M.D., ERASTUS I. GULLER, M.D.PAUL H. GARVEY, M.D.Search for more papers by this author, PAUL M. LEVIN, M.D.Search for more papers by this author, ERASTUS I. GULLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-11-1441 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of pernicious anemia with liver, introduced by Minot and Murphy1in 1926, after the experimental work of Whipple and his associates, has had a remarkable effect on the clinical course of the disease. The response of the nervous manifestations has been discussed by various authors with considerable difference of opinion. This is due partly to the use of different criteria in evaluating the results of treatment. Some observers have relied on improvement of symptoms not necessarily dependent upon structural restoration, while others have based their conclusions on the rigid interpretation of abnormal neurologic signs. Another cause for confusion...Bibliography1 MINOTMURPHY GRWP: Treatment of pernicious anemia by a special diet, Jr. Am. Med. Assoc., 1926, lxxxvii, 470-476. CrossrefGoogle Scholar2 CONNER HM: Improvement of neurologic manifestations of pernicious anemia; report of case, Proc. Staff Meet., Mayo Clinic, 1928, iii, 454. Google Scholar3 GILDEAKATTWINKELCASTLE EFEWB: Experimental combined system disease, New Eng. Jr. Med., 1930, ccii, 523-527. CrossrefGoogle Scholar4 MELLANBY E: The experimental production and prevention of degeneration in the spinal cord, Brain, 1931, liv, 247-290. CrossrefGoogle Scholar5 HALLHIRSCH GWEF: Paraplegia in flexion, with subacute combined degeneration of cord, Arch. Neur. and Psychiat., 1930, xxiii, 257-265. CrossrefGoogle Scholar6 CURSCHMANN H: Die Nervenstörungen der Biermerschen Anämie und die Lebertherapie, Deutsch. Ztschr. f. Nervenh., 1929, cxi, 151-159. CrossrefGoogle Scholar7 UNGLEYSUZMAN CCMM: Subacute combined degeneration of the cord: symptomatology and effects of liver therapy, Brain, 1929, lii, 271-294. CrossrefGoogle Scholar8 SMITHBURNZERFAS KCLG: The neural symptoms and signs in pernicious anemia: the effects of liver extract, Arch. Neur. and Psychiat., 1931, xxv, 1100-1110. CrossrefGoogle Scholar9 NEEDLES W: Neurologic complications of pernicious anemia; effects of treatment with liver; a preliminary report, Arch. Neur. and Psychiat., 1931, xxvi, 346-358. CrossrefGoogle Scholar10 DAVISON C: Subacute combined degeneration of the cord: changes following liver therapy; a histopathologic study, Arch. Neur. and Psychiat., 1931, xxvi, 1195-1219. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York*Received for publication July 29, 1932.†From the Department of Medicine, University of Rochester School of Medicine, and the Medical Clinic of the Strong Memorial and Rochester Municipal Hospitals. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Erkrankungen des erythrocytären SystemsFunikuläre Spinalerkrankungen 1 May 1933Volume 6, Issue 11Page: 1441-1448KeywordsHospital medicineLiverLiver diseasesPernicious anemia ePublished: 1 December 2008 Issue Published: 1 May 1933 PDF downloadLoading ...