THE EFFECT OF THIAMIN ON THE RESIDUAL NEURAL DISTURBANCES OF TREATED PERNICIOUS ANEMIA

Abstract

Article1 July 1941THE EFFECT OF THIAMIN ON THE RESIDUAL NEURAL DISTURBANCES OF TREATED PERNICIOUS ANEMIAJ. C. ZILLHARDT, M.D., KEITH MACLEAN, M.D., WILLIAM P. MURPHY, M.D.J. C. ZILLHARDT, M.D.Search for more papers by this author, KEITH MACLEAN, M.D.Search for more papers by this author, WILLIAM P. MURPHY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-1-33 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBy supplying sufficient amounts of anti-pernicious anemia substance it is possible to control the neural disturbances of uncomplicated Addisonian anemia. Certain residual neural manifestations are apt to remain, however, in spite of adequate liver therapy. This is particularly true in patients with advanced nervous system involvement and in those who have not been adequately treated at the onset.Considerable thought has been given the various vitamins1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11in connection with pernicious anemia and its associated neural disturbances. At the blood clinic of the Peter Bent Brigham Hospital interest became focused on...Bibliography1. CONNOR HM: Improvement of neurologic manifestations of pernicious anemia, Proc. Staff Meet. Mayo Clin., 1928, iii, 454. Google Scholar2. GARVEYLEVINGULLER PHPMEI: The effect of liver therapy on the neurologic aspects of pernicious anemia, ANN. INT. MED., 1933, vi, 1441. Google Scholar3. GILDEAKATTWINKELCASTLE EFEEWB: Experimental combined system disease, New Eng. Jr. Med., 1930, ccii, 523-527. CrossrefGoogle Scholar4. GILDEACASTLEGILDEACOBB MCWBEFS: Neuropathology of experimental vitamin deficiency, Am. Jr. Path., 1935, xi, 669. Google Scholar5. BERGEL A: Ein Behandlungserfolg bei funikulärer Myelose mittels Vitamin B1 (Betabion), Deutsch. med. Wchnschr., 1936, lxii, 1643. Google Scholar6. LASCH F: Ein erfolgreich mit Vitamin B1 behandelter Fall von schwerer funikulärer Myelose, München. med. Wchnschr., 1936, lxxxiii, 1390. Google Scholar7. WILLIAMSSPIES RRTD: Vitamin B1 and its uses in medicine, 1938, Macmillan Company, New York. Google Scholar8. WINTROBEMITCHELLKOLB MMDMLC: Sensory neuron degeneration in deficiency, Jr. Exper. Med., 1938, lxviii, 207-220. CrossrefGoogle Scholar9. MILLERRHODES DKCP: The experimental production of loss of hematopoietic elements of the gastric secretion and of the liver in swine with achlorhydria and anemia, Jr. Clin. Invest., 1935, xiv, 153. CrossrefGoogle Scholar10. MELLANBY E: The experimental production and prevention of degeneration in the spinal cord, Brain, 1931, liv, 247. CrossrefGoogle Scholar11. SUZMANMULLERUNGLEY MMGLCC: An attempt to produce spinal cord degeneration in dogs fed a high cereal diet deficient in vitamin A, Am. Jr. Physiol., 1932, ci, 529. CrossrefGoogle Scholar12. MURPHY WP: Anemia in practice, 1939, W. B. Saunders Co., Philadelphia. Google Scholar13. GRINKER RR: Neurology, 1937, Charles C. Thomas, Springfield, Ill. Google Scholar14. GREENFIELDO'FLYNN JGE: Subacute combined degeneration and pernicious anemia, Lancet, 1933, ii, 62. CrossrefGoogle Scholar15. COHEN H: Subacute combined degeneration of the spinal cord, Lancet, 1935, i, 1291. CrossrefGoogle Scholar16. GRINKERKANDEL RRE: Results of treatment of the neurologic complications of pernicious anemia, Arch. Int. Med., 1934, liv, 851. CrossrefGoogle Scholar17. BRAIN WR: Subacute combined degeneration, Oxford University Press, New York. Google Scholar18. KENNEDY F: Cecil, Text Book of Medicine, 1937, W. B. Saunders Co., Philadelphia. Google Scholar19. BRAIN WR: Subacute combined degeneration, Brit. Med. Jr., 1935, ii, 1056. CrossrefGoogle Scholar20. GREENFIELDCARMICHAEL JGEA: The peripheral nerves in cases of subacute combined degeneration of the cord, Brain, 1935, lviii, 483. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 30, 1940.From the Medical Clinic of the Peter Bent Brigham Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPernicious Anemia 1 July 1941Volume 15, Issue 1Page: 33-43KeywordsBloodHospitalsLiverNervous systemPernicious anemiaResearch laboratoriesThiamine Issue Published: 1 July 1941 PDF downloadLoading ...