Abstract
The effect of l-thyroxine on histidine metabolism in rat liver has been investigated. Daily intraperitoneal injections of 0.25 mg l-thyroxine for 10 dyas to male Wistar rats of 230 g body weight caused the following changes in the total activity of liver enzymes: histidine ammonia-lyase activity dropped from 21.5 to 27.8 units, urocanase dropped from 358.1 to 136.2 units, but histidine-pyruvate aminotransferase activity rose from 115.5 to 232.5 units. These results are all significant at the level of P < 0.001, and show that high doses of thyroxine enhance the transamination pathway of histidine metabolism.
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