Abstract
By recording the neuron unit discharges we have observed the effect of iontophoresis of gamma amino butyric acid (GABA) and glycine on the electrical activity of three different types of neurons in mesencephalic reticular formation (MRF). The results indicated that both GABA and glycine have a significant inhibitory effect on the spontaneous discharges of all three types of neurons and the pain discharges of the “pain excitatory type” neurons, and this inhibitory effect can be abolished by their corresponding antagonists, picrotoxin and strychnine. In combination with known histochemical data the results suggest that GABA and glycine might be endogenous transmitters in MRF.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have