Abstract
Approximately 2–10% of pregnancies are complicated by pre‐eclampsia. The pathophysiology of pre‐eclampsia is general arteriolar constriction and increased vascular sensitivity to precursor peptides and amines. The etiology of pre‐eclamsia is unknown. We examined (105 gravids) prospectively, the correlation between intra‐ and extracelullar magnesium deficit and uterine artery Doppler in women with pre‐eclampsia. We used bilateral early diastolic notch at 24 weeks as the definition of an abnormal waveform (circulatory parameters: Pi, Ri, of gravids art. uterina were excluded). For evaluation of RBC and plasma magnesium and calcium level we used atomic absorption spectrophotometry (AAS). According to our results, in majority of cases, we determined significantly low level of intracellular magnesium 0.86 + 0.22 mmol/L in group with bilateral notch, and positive correlation between bilateral notch, intercellular magnesium deficiency, increase level of intracellular calcium (0.69 + 0.18 mmol/L) and pre‐eclampsia. These results support hypothesis that misbalance of intracellular electrolytes, especially, intracellular magnesium and calcium are strong determinants of risk of pre‐eclampsia because these facts could cause grater excitability of vascular smooth muscle contraction.
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