Abstract
IT IS well known that the removal of three quarters of the anterior lobe of the pituitary often results in no detectable endocrine deficiency, and that in order for the usual atrophic endocrine changes that follow hypophysectomy to appear, removal of the pituitary must be essentially complete. On the other hand, relatively little attention has been paid to the effect on the target endocrine organs of removal of more than 75% but less than all of the anterior pituitary. Because of growing interest in the effect of anterior pituitary transplantation and hypothalamic lesions on endocrine function, this problem is of considerable interest and importance. The present study was therefore undertaken to determine the effect of removing graded amounts of anterior pituitary tissue on gonadal, thyroid and adrenocortical structure and function in the dog.
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