Abstract
The present study investigated the effect of anterior and posterior hypothalamic lesions on lethal anaphylaxis in the rat. Three groups of animals—control, posterior hypothalamic lesioned, and anterior hypothalamic lesioned—were sensitized to ovalbumin and subsequently challenged with various doses of the antigen. Dose-mortality curves were plotted for the control and two experimental groups. The three curves were demonstrated to be parallel. Ovalbumin was significantly less potent in the animals with anterior hypothalamic lesions than in both the control rats and those with posterior lesions. The protective action of anterior hypothalamic lesions against lethal anaphylaxis in the rat is discussed in terms of neuroendocrine processes, parasympathetic-sympathetic effects and antibody formation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
