Abstract
Long-term peritoneal dialysis (PD) can lead to detrimental changes in peritoneal membrane function, which may be related to the accumulation of glucose degradation products. A previous study demonstrated that 6 months of far-infrared (FIR) therapy may decrease glucose degradation products in PD dialysate. Due to limited literature on this matter, this study aims to investigate the effect of FIR therapy on the peritoneal membrane transport characteristics of PD patients. Patients were grouped according to baseline peritoneal transport status: lower transporters (low and low-average) and higher transporters (high-average and high). Both groups underwent 40 min of FIR therapy twice daily for 1 year. In lower transporters, FIR therapy increased weekly dialysate creatinine clearance (6.91 L/wk/1.73 m2; p = 0.04) and D/P creatinine (0.05; p = 0.01). In higher transporters, FIR therapy decreased D/P creatinine (−0.05; p = 0.01) and increased D/D0 glucose (0.05; p = 0.006). Fifty percent of high transporter patients shifted to high-average status after FIR therapy. FIR therapy may decrease D/P creatinine for patients in the higher transporter group and cause high transporters to shift to high-average status, which suggests the potential of FIR therapy in improving peritoneal membrane function in PD patients.
Highlights
Peritoneal dialysis (PD) has been proven to be an alternate choice compared to hemodialysis as a type of maintenance renal replacement therapy for patients with endstage renal disease (ESRD) [1]
Previous studies have reported the non-thermal properties treatment using infrared radiation, such as (1) inhibiting endothelial inflammation via heme oxygenase-1 (HO-1) induction that may lead to preserving the patency of arteriovenous fistulas in hemodialysis patients (FIR therapy) [10], (2) inhibiting neointimal hyperplasia in rabbits by decreasing the proliferation of vascular smooth muscle cells, possibly reducing the frequency of vascular access stenosis [11], and (3) improving endothelial function by decreasing urinary 8-epi-prostaglandin F2α levels in patients with coronary risk factors, [12] and reducing serum advanced glycation end-products and diabetes-induced inflammatory markers in the vascular endothelium of diabetic mice (FIR therapy) [13]
This study aims to investigate the long-term effect of FIR therapy on the peritoneal membrane transport characteristics of ESRD patients on peritoneal dialysis (PD)
Summary
Peritoneal dialysis (PD) has been proven to be an alternate choice compared to hemodialysis as a type of maintenance renal replacement therapy for patients with endstage renal disease (ESRD) [1]. Previous studies have reported the non-thermal properties treatment using infrared radiation, such as (1) inhibiting endothelial inflammation via heme oxygenase-1 (HO-1) induction that may lead to preserving the patency of arteriovenous fistulas in hemodialysis patients (FIR therapy) [10], (2) inhibiting neointimal hyperplasia in rabbits by decreasing the proliferation of vascular smooth muscle cells, possibly reducing the frequency of vascular access stenosis (non-ablative infrared laser therapy) [11], and (3) improving endothelial function by decreasing urinary 8-epi-prostaglandin F2α levels (oxidative stress marker) in patients with coronary risk factors (sauna therapy), [12] and reducing serum advanced glycation end-products and diabetes-induced inflammatory markers in the vascular endothelium of diabetic mice (FIR therapy) [13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
