The Authors Reply:

Abstract

We thank Dr Coronel for his comments.1.Coronel F. Effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on peritoneal transport.Kidney Int. 2011; 79: 136-137Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar Indeed, over two decades ago, Coronel et al.2.Coronel F. Hortal L. Naranjo P. et al.Captopril, proteinuria and peritoneal protein leakage in diabetic patients.Nephron. 1989; 51: 443Crossref PubMed Scopus (13) Google Scholar examined the effects of blockade of the renin–angiotensin–aldosterone system (RAAS) on peritoneal membrane function. Although the two studies mentioned were both small with a short exposure time to RAAS blocking agents,2.Coronel F. Hortal L. Naranjo P. et al.Captopril, proteinuria and peritoneal protein leakage in diabetic patients.Nephron. 1989; 51: 443Crossref PubMed Scopus (13) Google Scholar, 3.Coronel F. Berni A. Cigarran S. et al.Effects of angiotensin II receptor blocker (irbesartan) on peritoneal membrane functions.Adv Perit Dial. 2004; 20: 27-30PubMed Google Scholar they were the earliest studies to report the effect of blocking the RAAS on peritoneal membrane function in peritoneal dialysis patients, setting the stage for the subsequent, larger-scale observational studies by Kolesnyk et al.4.Kolesnyk I. Dekker F.W. Noordzij M. et al.Impact of ACE inhibitors and AII receptor blockers on peritoneal membrane transport characteristics in long-term peritoneal dialysis patients.Perit Dial Int. 2007; 27: 446-453PubMed Google Scholar, 5.Kolesnyk I. Noordzij M. Dekker F.W. et al.A positive effect of AII inhibitors on peritoneal membrane function in long-term PD patients.Nephrol Dial Transplant. 2009; 24: 272-277Crossref PubMed Scopus (58) Google Scholar Unfortunately, we were limited in the number of references for this mini-review, and did not have the opportunity to discuss these smaller early studies.